Nonlinear analysis of physiological variables in the assessment of adaptation to physical effort

Małgorzata Żebrowska

supervisor: Jan Jacek Żebrowski



The analysis of adaptation processes in the living organisms can be considered on different function and organization levels. Recurring disturbances in body homeostasis, caused by physical effort, inducing adaptive changes in individual organs, physiological systems and comprehensively throughout the whole organism. The scope of the study includes the identification of physiological markers that can be used as non-invasive diagnostic tools to describe the adaptation processes occurring during physical effort. The assessment of couplings detection and quantitative characterization of theirs direction and strength is considered. The methodology assumes the development, testing and verification of the application of non-linear signal analysis methods used to characterize the couplings and the complexity of time series. As part of the potential tools, the entropy and correlation measures, both in classical and symbolic terms, will be considered, e.g. symbolic transfer entropy, mutual information, Granger causality. It is also planned to verify the methods of signal processing in the frequency domain, including empirical mode decomposition and Hilbert transform for the classification of fatigue development. The analyzes will be conducted on the basis of medical data, for groups of healthy people registered during cardiopulmonary exercise tests.